What's New

Now Available: New Kinase Panel Rollout - 451 Kinase Assays!

The biggest in class kinase assay panel just got bigger & better!

KINOMEscan™, a leading provider of kinase inhibitor profiling services with the largest commercially available kinase assay panel, is excited to announce the expansion of its kinase assay panel with the release of nine new assays!
 
Now with 451 kinase assays, KINOMEscan continues to redefine the standard in selectivity profiling by providing high value kinase assays and screening solutions to drive kinase drug discovery.

New Kinase Assay Panel Highlights

  • Novel activation-state specific autoinhibited assay pairs - identify and optimize activation-state sensitive inhibitors
  • Expanded scanMODE assay panel - characterize inhibitor binding mode
  • Expanded scanTK assay panel enables broader assessment
  • Includes additions to CAMK, AGC, TK & Other kinase group assays


View Press Release >>

Now Available New Kinase Assays

Circles represent kinase assays currently available in the KINOMEscan panel, blue circles represent new assays (Click to view larger image).

 New Kinase Assays

KINOMEscan Gene Symbol Entrez Gene Symbol Accession No. Kinase Group Species
BUB1 BUB1 NP_004327.1 Other Human
CSF1R-autoinhibited CSF1R NP_005202.2 TK Human
FLT3-autoinhibited FLT3 NP_004110.2 TK Human
HASPIN GSG2 NP_114171.2 Other Human
KIT-autoinhibited KIT NP_000213.1  TK Human
RSK2(Kin.Dom.2-C-terminal) RPS6KA3 NP_004577.1  CAMK Human
SGK SGK1 NP_005618.2  AGC Human
WNK1 WNK1 NP_061852.3 Other Human
WNK3 WNK3 NP_065973.2  Other Human


What are autoinhibited assays?
KINOMEscan autoinhibited/non-autoinhibited PDGFR family RTK assay pairs represent the next generation of activation state-specific kinase assays that may be used to gain structural insights in the absence of cocrystal data and to collect in vitro data most predictive of inhibitor potency in cellular assays.

  • Reports on the compatibility of an inhibitor’s binding mode with the autoinhibited conformation
  • Collect activation state-specific biochemical PDGFR family RTK inhibition data necessary to predict & interpret potency in cellular assays
  • Further differentiate inhibitors based on activation state-specific binding
  • Explore & exploit inhibitor binding to diverse activation state-dependent kinase conformations

    Learn more about KINOMEscan autoinhibited kinase assays >>