Overview of KINOMEscan Solutions & Services
Cell-Based Kinase Profiling Services - Now Available Through DiscoveRx!
Services & Solutions
Maximize the value of your compound libraries. Rapidly screen hundreds or thousands of compounds against any KINOME
scan kinase panel or individual target from our broad portfolio of kinase assays.
A flexible 'a la carte' approach to personalized kinase profiling. Select from KINOME
scan's collection of 451 kinase assays and rapidly deploy a customized assay panel of any size comprised only of kinases relevant to your programs.
An economical approach to surveying the human kinome,
scanEDGE includes 96 kinases distributed throughout the AGC, CAMK, CMGC, CK1, STE, TK, TKL, lipid, and atypical kinase families, plus important mutant forms.
The largest commercial kinase panel available,
scanMAX contains a definitive set of 451 kinases covering AGC, CAMK, CMGC, CK1, STE, TK, TKL, lipid and atypical kinase families, plus important mutant forms.
scanTK is the largest commercial panel of tyrosine kinases and includes a definitive set of 130 kinases containing both receptor and non-receptor kinases, plus important mutant forms.
The largest commercial collection of human lipid kinase assays available,
scanLIPID contains a panel of PI3K, PI4K, PIP plus clinically relevant mutants and represents an ideal solution, alone or paired with additional relevant kinases, to explore this attractive target class.
Employs activated/non-activated & autoinhibited/non-autoinhibited assay pairs to elucidate compound binding mode. An ideal tool for exploring and understanding how kinase activation state affects inhibitor affinity.
Quantitate compound binding affinity against any KINOME
scan kinase assay. Inhibitor binding constants (Kd values) are calculated from duplicate 11-point dose-response curves (plus DMSO control). Measurements are made under optimized conditions that generate true thermodynamic Kd values.
Complete Kd profile of the
scanMAX panel. Recommended for candidate compounds
Learn more about your kinase inhibitor’s biochemical mechanism of action. KINOMEscan offers a suite of investigative tools that provides a detailed biochemical characterization of the interaction between inhibitors and their targets. The thermodynamic, kinetic, and structural information provided by these tools enables a detailed comparison of inhibitors from common or distinct lead series and facilitates the interpretation of data from downstream cellular and in vivo pharmacology models.
The PathHunter® Cell-Based Kinase Screening and Profiling Service leverages DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) Assay Technology in a whole cell platform enabling customers to interrogate and characterize compounds in a more physiologically relevant context.