scanUnique

See What You're Missing

When it comes to kinase selectivity and off-target profiling, kinase panel size matters! Larger panels provide not only a better measure of compound selectivity, but a more comprehensive view of potential off-target activity that smaller panels may overlook. 

With more than 170 distinct assays compared to the next leading service provider and more than 70 assays available only through KINOMEscan, it’s no surprise that more researchers are turning to us to help drive discovery and SAR.

See for yourself how KINOMEscan compares to the competition using our scanUNIQUE Delta Set panels, or contact us to receive more information about the assays missing in your current solution provider's portfolio. Then request a quote to see what you're missing!
 

Panel Highlights and Benefits

  • More than 80% coverage of the human protein kinome
  • High-quality reproducible data
  • Rapid turnaround time
  • Broad dynamic range: can detect compounds with Kds <100 pM to >10 mM
  • Flexible - Standard and custom panels
  • Activation-state specific assays
  • Detection of multiple inhibitor types (e.g. type I, II & non-ATP competitive)
scanMAX Kinase Dendrogram

Red circles represent the kinases currently available in the KINOMEscan panel.

JAK Inhibitor TG-101348

JAK2 Inhibitor small panel versus large panel selectivity
Selectivity of JAK inhibitor TG-101348 was reported in published findings to be a selective pan-JAK inhibitor on the basis of kinase profiling against a panel of 37 kinases.  In contrast, selectivity profiling against the scanMAX kinase assay panel (then 402) revealed additional interactions not previously identified [click graph to enlarge]. 

RSK Inhibitor BI-D1870

RSK Inhibitor small panel versus large panel selectivity
Selectivity of RSK inhibitor BI-D1870 was reported in published findings to be a selective RSK kinase inhibitor on the basis of kinase profiling against a panel of 54 kinases.  In contrast, selectivity profiling against the scanMAX kinase assay panel (then 402) revealed additional interactions not previously identified [click graph to enlarge].