ABL1(F317I)-phosphorylated
KINASE INFORMATION
Kinase Name
c-abl oncogene 1, receptor tyrosine kinase
Entrez Gene Symbol
ABL1
Entrez Gene ID
25
Aliases
ABL; ABL1; bcr/abl; c-ABL; JTK7; p150; v-abl
Kinase Group
TK
Species
Human
Phosphorylated
yes
PROTEIN INFORMATION
Accession #
NP_005148.2
Kinase Construct
Partial Length
Kinase Form
Mutation (F317I)
Mutation Relevance
Mutatin confers dasatinib-resistance in cell culture.
Mutation References
Proc Natl Acad Sci USA.
102, 3395-3400 (2005)
Blood.
108, 2332-2338 (2006)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.73
Panel
scanELECT; scanMAX; scanMODE; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd