BRAF(V600E)
KINASE INFORMATION
Kinase Name
v-raf murine sarcoma viral oncogene homolog B1
Entrez Gene Symbol
BRAF
Entrez Gene ID
673
Aliases
BRAF; BRAF1; B-RAF1; FLJ95109; MGC126806; MGC138284; RAFB1
Kinase Group
TKL
Species
Human
PROTEIN INFORMATION
Accession #
NP_004324.2
Kinase Construct
Partial Length
Kinase Form
Mutation (V600E)
Mutation Relevance
Activating mutation found in malignant melanoma.
Mutation References
Nature.
417, 949-954 (2002)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.78
Panel
scanEDGE; scanELECT; scanMAX;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
AMG-706
280 nM
CHIR-265/RAF-265
330 nM
Dasatinib
570 nM
Sorafenib
260 nM