EGFR(L858R,T790M)
KINASE INFORMATION
Kinase Name
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Entrez Gene Symbol
EGFR
Entrez Gene ID
1956
Aliases
EGFR; ERBB; ERBB1; HER1; mENA; PIG61
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_005219.2
Kinase Construct
Partial Length
Kinase Form
Mutation (L858R,T790M)
Mutation Relevance
T790M mutation confers gefitinib- and erlotinib-resistance in non-small-cell lung cancer (NSCLC).
Mutation References
N Engl J Med.
352, 2136 (2005)
PLoS Med.
2, e73 (2005)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.73
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
CEP-701
30 nM
CGP-52421
35 nM
PKC-412
26 nM