EGFR(L861Q)
KINASE INFORMATION
Kinase Name
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Entrez Gene Symbol
EGFR
Entrez Gene ID
1956
Aliases
EGFR; ERBB; ERBB1; HER1; mENA; PIG61
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_005219.2
Kinase Construct
Partial Length
Kinase Form
Mutation (L861Q)
Mutation Relevance
EGFR inhibitor sensitizing mutation in non-small-cell lung cancer (NSCLC).
Mutation References
N Engl J Med.
350, 2129-2139 (2004)
Expression System
Bacterial
ASSAY INFORMATION
Average Z’ Value
0.62
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
CI-1033
0.22 nM
EKB-569
0.44 nM
Erlotinib
1.2 nM
Gefitinib
1.4 nM
Lapatinib
1.2 nM