EGFR(T790M)
KINASE INFORMATION
Kinase Name
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Entrez Gene Symbol
EGFR
Entrez Gene ID
1956
Aliases
EGFR; ERBB; ERBB1; HER1; mENA; PIG61
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_005219.2
Kinase Construct
Partial Length
Kinase Form
Mutation (T790M)
Mutation Relevance
T790M mutation confers gefitinib- and erlotinib-resistance in non-small-cell lung cancer (NSCLC).
Mutation References
Cancer Res.
66, 7854-7858 (2006)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.74
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
K-252a
40 nM
Purvalanol B
410 nM
Staurosporine
0.77 nM