FGFR3(G697C)
KINASE INFORMATION
Kinase Name
fibroblast growth factor receptor 3
Entrez Gene Symbol
FGFR3
Entrez Gene ID
2261
Aliases
ACH; CD333; CEK2; FGFR3; HSFGFR3EX; JTK4
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_000133.1
Kinase Construct
Partial Length
Kinase Form
Mutation (G697C)
Mutation Relevance
Activating mutation found in oral squamous cell carcinoma.
Mutation References
Int J Cancer.
117, 166-168 (2005)
Expression System
Bacterial
ASSAY INFORMATION
Average Z’ Value
0.7
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
CEP-701
730 nM
CHIR-258/TKI-258
370 nM
Pazopanib
620 nM
SU-14813
380 nM
Sunitinib
1400 nM