FLT3(D835Y)
KINASE INFORMATION
Kinase Name
fms-related tyrosine kinase 3
Entrez Gene Symbol
FLT3
Entrez Gene ID
2322
Aliases
CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_004110.2
Kinase Construct
Partial Length
Kinase Form
Mutation (D835Y)
Mutation Relevance
Activating mutation found in acute myeloid leukemia (AML).
Mutation References
Blood.
97, 2434-2439 (2001)
Br J Haematol.
113, 983-988 (2001)
Expression System
Bacterial
ASSAY INFORMATION
Average Z’ Value
0.66
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
ABT-869
11 nM
CEP-701
0.57 nM
CHIR-258/TKI-258
5.2 nM
MLN-518
1800 nM
PKC-412
15 nM
Sunitinib
2.3 nM