FLT3(ITD)
KINASE INFORMATION
Kinase Name
fms-related tyrosine kinase 3
Entrez Gene Symbol
FLT3
Entrez Gene ID
2322
Aliases
CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_004110.2
Kinase Construct
Partial Length
Kinase Form
Mutation (ITD)
Mutation Relevance
Activating mutation found in acute myeloid leukemia (AML).
Mutation References
Leukemia.
10, 1911-1918 (1996)
Expression System
Bacterial
ASSAY INFORMATION
Average Z’ Value
0.76
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
ABT-869
8.8 nM
CEP-701
1.5 nM
CHIR-258/TKI-258
3.6 nM
MLN-518
9.1 nM
PKC-412
11 nM
Sunitinib
0.99 nM