FLT3(R834Q)
KINASE INFORMATION
Kinase Name
fms-related tyrosine kinase 3
Entrez Gene Symbol
FLT3
Entrez Gene ID
2322
Aliases
CD135; FLK2; FLK-2; FLT3; FLT-3; Ly72; STK1
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_004110.2
Kinase Construct
Partial Length
Kinase Form
Mutation (R834Q)
Mutation Relevance
Activating mutation found in acute myeloid leukemia (AML).
Mutation References
Cancer Cell.
12, 501–513 (2007)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.56
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
K-252a
11 nM
Purvalanol B
620 nM
Staurosporine
0.22 nM