MET(Y1235D)
KINASE INFORMATION
Kinase Name
met proto-oncogene (hepatocyte growth factor receptor)
Entrez Gene Symbol
MET
Entrez Gene ID
4233
Aliases
AUTS9; c-Met; HGFR; MET; RCCP2
Kinase Group
TK
Species
Human
PROTEIN INFORMATION
Accession #
NP_000236.2
Kinase Construct
Partial Length
Kinase Form
Mutation (Y1235D)
Mutation Relevance
Activating mutation found in lymph node metastases of head and neck squamous-cell carcinomas.
Mutation References
Oncogene.
19, 1547-1555 (2000)
Biochemistry.
44, 14110-14119 (2005)
Expression System
Bacterial
ASSAY INFORMATION
Average Z’ Value
0.66
Panel
scanELECT; scanMAX; scanTK;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
CEP-701
30 nM
PKC-412
560 nM
Sunitinib
4700 nM