PIK3CA(I800L)
KINASE INFORMATION
Kinase Name
phosphoinositide-3-kinase, catalytic, alpha polypeptide
Entrez Gene Symbol
PIK3CA
Entrez Gene ID
5290
Aliases
MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA
Kinase Group
Lipid
Species
Human
PROTEIN INFORMATION
Accession #
NP_006209.2
Kinase Construct
Partial Length
Kinase Form
Mutation (I800L)
Mutation Relevance
A potential hotspot for resistance mutations. Resistant to PI-103 but sensitized to NVP-BEZ-235.
Mutation References
Cancer Cell.
14, 180–192 (2008)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.59
Panel
scanELECT; scanLIPID; scanMAX;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
Wortmannin
81 nM