PIK3CA(M1043I)
KINASE INFORMATION
Kinase Name
phosphoinositide-3-kinase, catalytic, alpha polypeptide
Entrez Gene Symbol
PIK3CA
Entrez Gene ID
5290
Aliases
MGC142161; MGC142163; p110-alpha; PI3K; PIK3CA
Kinase Group
Lipid
Species
Human
PROTEIN INFORMATION
Accession #
NP_006209.2
Kinase Construct
Partial Length
Kinase Form
Mutation (M1043I)
Mutation Relevance
Activating mutation found in diverse cancers.
Mutation References
Cancer Res.
65, 4562-4567 (2005)
Expression System
Mammalian
ASSAY INFORMATION
Average Z’ Value
0.66
Panel
scanELECT; scanLIPID; scanMAX;
REFERENCE INHIBITOR INFORMATION
Compound
Kd
CEP-701
1100 nM
Wortmannin
11 nM