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RET(V804M)

KINASE INFORMATION

Kinase Name ret proto-oncogene
Entrez Gene Symbol RET
Entrez Gene ID 5979
Aliases CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET51; RET-ELE1
Kinase Group TK
Species Human

PROTEIN INFORMATION

Accession # NP_065681.1
Kinase Construct Partial Length
Kinase Form Mutation (V804M)
Mutation RelevanceActivating mutation found in multiple endocrine neoplasias and familial medullary thyroid carcinomas.
Mutation ReferencesOncogene. 23, 6056-6063 (2004)
Expression System Bacterial

ASSAY INFORMATION

Average Z’ Value 0.7
Panel scanELECT; scanMAX; scanTK;

REFERENCE INHIBITOR INFORMATION

CompoundKd
AC2209.1 nM
CEP-7014.7 nM
CGP-52421260 nM
PKC-41220 nM
Sorafenib22 nM
Sunitinib5.8 nM

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